September 22-26, 2014
Building 10
- General Schedule of Events
- Opening Plenary Session
- Concurrent Symposia Sessions
- Poster Sessions
- FARE Award Ceremony
- Special Exhibits on Resources for Intramural Research
- TSA Research Festival Exhibit Show
- Clinical Center Tours
- Research Festival Committees
- Past Research Festivals
2014 program
Download the 2014 Research Festival Schedule Overview (6 pages)
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Characterization of Antibody Interactions to Influenza Hemagglutinin
| Tuesday, September 23, 2014 — Poster Session III | |||
|---|---|---|---|
12:00 p.m. – 2:00 p.m. |
FAES Academic Center |
NIAID |
VIROL-7 |
Authors
- DM McCraw
- AK Harris
Abstract
Hemagglutinin (HA) is the major surface glycoprotein to which neutralizing antibodies are elicited for Influenza virus. Neutralizing epitopes reside in both the head region composed of HA1 globular domains and the stem region composed of HA2 domains. Highly conserved epitopes within the stem region of HA2 are the targets of a number of broadly neutralizing antibodies and hold promise for the design a universal influenza vaccine. However, it is still unclear what strategies will prove successful in engineering a vaccine that promotes broadly neutralizing antibodies to conserved HA epitopes. Here, we used structural informatics approaches in which we combined structural, biochemical, and immunological analyses in order to understand HA antigen-antibody interactions and we identified factors that influence hemagglutinin-antibody engagement.
