Molecular Logic of Angiogenesis in Development and Disease

Tuesday, October 25, 2011 — Concurrent Symposia Session II
10:00 a.m. – Noon	Balcony C

Co-chairs

• Yosuke Mukoyama, NHLBI
• Xuri Li, NEI

Program

Angiogenesis plays central roles in organ development as well as organ maintenance, tissue repair, and diverse disease conditions. This symposium will discuss advances in angiogenesis research with an emphasis on molecular events underlying vascular development and disease. Lessons learned from developmental studies in model organisms have been applied to questions concerning not only genetic programs that govern blood-vessel formation, but paracrine signals between blood vessels and surrounding target tissues that support cell-fate decisions and patterning. In disease studies, dysregulated vessel formation contributes to numerous malignant, ischemic, inflammatory, infectious, and immune disorders. Molecular insights into these processes provide new therapeutic opportunities. By virtue of these diverse elements of vascular biology, an integrated view of angiogenesis linking developmental pathways and disease pathogenesis with multiple vasculature models will be presented by senior and junior investigators from four institutes (NHLBI, NEI, NCI, and NICHD).

Neuronal Control of Vascular Fate and Branching Pattern in Developing Skin Vasculature
Yosuke Mukoyama, NHLBI

A Fishes-Eye View of Angiogenesis
Brant Weinstein, NICHD

EphrinB2: A Critical Regulator of Endothelial Cell Function and Vascular Integrity
Giovanna Tosato, NCI

TEM8 Blockade Results in Broad Anti-Tumor Activity Through Inhibition of Host Tumor Vasculature *FARE Award Winner
Amit Chaudhary, NCI

Arterial Calcification Due to Deficiency in CD73: The Role of Extracellular Purine Metabolism in Patients With Vascular Calcification
Manfred Boehm, NHLBI

Angiogenesis in Eye Development and Disease
Xuri Li, NEI

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