Opening Plenary Session:
Molecular Mechanisms of Human Disease

Monday, October 24, 2011 — Opening Plenary Session
10:00 a.m. – Noon	Masur Auditorium, Building 10

Co-chairs

• Gary Nabel, VRC
• Robert Wiltrout, NCI

Program

Information provided from the Human Genome Project, as well as the rapid advancement of enabling molecular technologies, have provided a foundation for new approaches to unravel the mysteries of many diseases. In particular, genetic and genomic information is allowing unprecedented insights into the aberrant functions of overexpressed, repressed or dysregulated genes in many disease settings, and allowing researchers to interrogate and identify specific molecular mechanisms associated with disease causation and progression. These new insights into the molecular etiology of disease are now being rapidly exploited to provide new targets for development of new therapeutic and/or prevention strategies. The Opening Plenary Session can be viewed via live videocast at http://videocast.nih.gov.

Understanding the Pathogenesis of Primary Immunodeficiencies Using Model Systems
Pamela Schwartzberg, NHGRI

Molecular Linkages Between Metabolic Imbalance, Genome Stability, and Breast Cancer
Kevin Gardner, NCI

From Phenotype to Function: Discovering Molecular Mechanisms of NF-?B Regulation through Forward Genetics of NEMO Syndrome *FARE Award Winner
Eric Hanson, NIAMS

Using Genetics to Understand the Neuropathology of Stuttering
Dennis Drayna, NIDCD

Locating the Achilles' Heel of Cancer Through Functional and Structural Genomics
Louis Staudt, NCI

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