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New Insights into Disease Pathogenesis and Treatment Through Genomewide RNAi Screening

Monday, October 24, 2011 — Concurrent Symposia Session I

2:00 p.m. – 4:00 p.m.

Ruth L. Kirschstein Auditorium


  • Natasha Caplen, NCI
  • Christopher Austin, NHGRI


The NIH Scientific Directors recently approved the establishment of a genome-wide RNAi screening facility at the NIH Chemical Genomics Center (NCGC) to perform collaborative projects with intramural investigators. This state-of-the-art facility is now fully operational and actively conducting large-scale screens with investigators from throughout the NIH. This symposium will highlight some of the exciting large-scale RNAi screening projects currently being executed at the Trans-NIH RNAi screening facility to illustrate the value of large-scale functional genomic approaches and to promote further interest in the use of this important new Trans-NIH resource.

Geminin: The Achilles' Heal Of Cancer Cells
Mel Depamphilis, NICHD

Genome-Wide siRNA Screening to Reveal DNA Replication Stress
Kyungjae Myung, NHGRI

RNAi Screening to Analyze Immunotoxin-Mediated Killing of Cancer Cells
David Fitzgerald, NCI

Identification and Characterization of Novel Regulators of Mouse Embryonic Stem Cell Identity *FARE Award Winner
Johannes Freudenberg, NIEHS

Functional and Chemical Genomic Approaches to Study the Mechanisms of Mitochondrial Quality Control Linked to Neurodegenerative Disease
Sam Hasson, NINDS

Genome-Wide RNAi Screening for Modifiers of Lysosomal Storage Disorders
Ellen Sidransky, NHGRI

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