Dynamic Protein Assemblies: Large and Small

Tuesday, October 25, 2011 — Concurrent Symposia Session III
2:00 p.m. – 4:00 p.m.	Balcony B

Co-chairs

• Sriram Subramaniam, NCI
• James Hurley, NIDDK

Program

The organization of proteins and other macromolecules into functional complexes is a central concept in biology. The complexes range from well-ordered symmetric assemblies with repeating units to heterogeneous multi-protein assemblies that display variable composition and stoichiometry, and range in size from many megadaltons to under 100 kilodaltons. This symposium features a collection of talks that will present progress on using NMR spectroscopy, X-ray crystallography, cryo-electron microscopy and computational modeling to unravel the structural and functional organization of a variety of biologically interesting protein complexes.

The Structure of the Iron-Import Machinery from Pathogenic Neisseria *FARE Award Winner
Nicholas Noinaj, NIDDK

Interactions between Proteins and Lipids Viewed by NMR Spectroscopy
Adriaan Bax, NIDDK

Too Big for NMR, Too Small for EM, and Too Floppy for X-rays: New Hybrid Approaches for Mid-Sized Dynamic Protein Complexes
James Hurley, NIDDK

Structures and Topology of Translated and Untranslated Regions of mRNA: Combined Approach to Structure Problems
Yun-Xing Wang, NCI

Needles in Haystacks: Mechanisms for Locating DNA Lesions
Wei Yang, NIDDK

Protein Structure Determination with Cryo-Electron Microscopy
Sriram Subramaniam, NCI

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