October 24 - 28, 2011
Building 10 & Natcher Conference Center
- General Schedule of Events
- Opening Plenary Session
- Concurrent Symposia Sessions
- Improving Workplace Dynamics
- FARE Award Ceremony
- Poster Sessions
- Special Exhibits on Resources for Intramural Research
- TSA Research Festival Exhibit Show
- Research Festival Committees
- Past Research Festivals
2011 program
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Structural basis for p300 Taz2-p53 TAD binding and modulation by phosphorylation
| Tuesday, October 25, 2011 — Poster Session II | |||
|---|---|---|---|
Noon – 2:00 p.m. |
Natcher Conference Center |
NCI |
STRUCTBIO-2 |
Authors
- H Feng
- L Jenkins
- S Durell
- R Hayashi
- S Mazur
- S Cherry
- J Tropea
- M Miller
- A Wlodawer
- E Appella
- Y Bai
Abstract
The CCR Molecular Modeling Core assists experimentalists across NIH by providing a structural framework for interpreting results and designing new experiments. As an example, we provide results of a study examining the interaction of the transactivating domain of the anti-tumor protein p53 with the Taz2 domain of p300 (a histone acetyltransferase coactivator). The model explains the experimentally observed effects of post-translational phosphorylation on binding affinity. The contact for the core is Stewart Durell: Stewart_Durell@nih.gov, (301) 402-4940.
