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SAIC-Frederick Pathology and Histotechnology Shared Services Core

Wednesday, October 26, 2011 — Poster Session III

10:00 a.m. – Noon

Natcher Conference Center




  • L Sternberg
  • M Anver
  • T Beachley
  • D Butcher
  • W Custer
  • G DiSalvo
  • X Hao
  • S Florea
  • D Green
  • Y Golubeva
  • D Haines
  • J Krolus
  • J Matta
  • T Morgan
  • G Rivera
  • R Oden
  • G Rivera
  • R Smith
  • S Smith
  • A Warner


The Pathology/Histotechnology Laboratory (PHL) provides comprehensive research support for NCI/NIH laboratories. The Veterinary Pathology Section is staffed by two board-certified veterinary pathologists who offer integrated pathology solutions from design of custom necropsy protocols through microscopic evaluation using a computerized data collection system. Expertise includes phenotyping of genetically engineered mice (GEM), immunopathology, evaluation of chromogenic in situ hybridization (CISH), and specimen selection for tissue microarrays and laser micro dissection (LCM). The Histotechnology Laboratory (HL) additionally offers other powerful tools for the phenotyping of GEM including hematology, blood chemistry, complex necropsy support, fixed and/or frozen tissue processing, microtomy, histological staining, CISH assay development and, immunohistochemistry (IHC). The HL also offers flexible nucleic acid isolation from fresh/fixed/frozen human and animal tissue, blocks, or precut slides that include goal-appropriate measures of quality. The group also supports a wide range of image capture and analysis goals including gross animal imaging, bright field and fluorescent microscopy and Aperio digital whole slide scanning with an option for digital slide conferencing via a secure server. The PHL has also banked a wide range of reagents that are used to facilitate research. An overview of group capabilities and representative projects are presented. Funded by NCI Contract HHSN261200800001E.

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