Influence of personality measures and priming effects on IV alcohol self-administration in social drinkers

Monday, October 24, 2011 — Poster Session I
Noon – 2:00 p.m.	Natcher Conference Center	NIAAA	PHARM/PHYS-4

Authors

• B Stangl
• V Vatsalya
• M Zametkin
• M Cooke
• V Ramchandani

Abstract

The CASE system is a laboratory method that allows individuals to choose to self-administer IV alcohol, while controlling the breath alcohol concentration (BrAC) using a physiologically-based pharmacokinetic model. The objective of this study was to examine the influence of subjective measures of alcohol effects and personality measures on intravenous alcohol self-administration in social drinkers. Participants underwent two self-administration sessions consisting of a 25-min priming phase where subjects were prompted to push a button to receive individually standardized alcohol infusions, followed by a 2-hour “open bar” phase with ad-lib access. Self-administration measures included number of button presses (NBP), peak (PEAK) and average (AVG) BrAC, and time to peak BrAC (TP). Subjective measures included DEQ, AUQ, SRE and AEFQ. Personality measures included the NEO-PI-R, UPPS-P Impulsive Behavior Scale, BIS and SPSRQ. Results indicated a positive correlation between motor and attentional impulsivity measures and AVG and PEAK. Sensitivity to reward and SRE measures were positively correlated with AVG, PEAK, and NBP. AEFQ measures were positively correlated with TP and NBP. DEQ measures of “liking” and “wanting” and AUQ total score were significantly associated with AVG, NBP and PEAK. Results support a relationship between impulsivity and priming effects of alcohol and alcohol intake behavior.

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