CMR diastolic function: relationship between 3D model-based assessment, mitral valve inflow phase contrast and echo-Doppler assessment

Wednesday, October 26, 2011 — Poster Session III
10:00 a.m. – Noon	Natcher Conference Center	CC	IMAG-25

Authors

• M Nacif
• A Young
• B Cowan
• E-Y Choi
• N Mewton
• O Gjesdal
• C Sibley
• V Sachdev
• H Hannoush
• A Zavodni
• N Kawel
• S Liu
• E Turkbey
• R Noureldin
• J Lima
• D Bluemke

Abstract

Aim: Assess the relationship between 3D volume based filling rate model, and the mitral valve inflow for diastolic function. Methods: Diastolic function was assessed based on flow (ml/s) using PC and 3D CMR, and compared to mitral valve velocity (cm/s) by echo-Doppler. Results: Diastolic parameters were compared in 170 assessments from 17 healthy volunteers (78% male; 44+15 years old; EF 61+6%). Peak E by PC and 3D correlated significantly (r=0.79, p<0.001), but quantification of E was overestimated by PC (309±97ml/s) compared to 3D (261±74ml/s) (p=0.004), the mean difference was 47.7 ml/s (+166.1 to – 70.5 - 95% LA). Peak A by PC and 3D correlated well (r=0.71, p<0.001). Quantification of A was overestimated by PC (243±63.0ml/s) compared to 3D (102±40ml/s; p<0.01). There was no significant difference between DT measured by 3D (222±22ms) or PC (202±58ms) by CMR and Doppler (207±18ms, ANOVA p>0.05). E/A assessed by PC (1.13±0.55) agreed well with Doppler assessment (1.07±0.24, p=0.61) with good correlation (r=0.86, p<0.01). Conclusions: Early and late ventricular filling rates by 3D CMR correlated well with PC mitral inflow velocity. The E/A ratio by PC correlated well with echo-Doppler results. DT assessment by CMR is feasible and results are not significantly different from echo-Doppler.

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