Myocardial T1 mapping using a Modified Look-Locker Inversion Recovery (MOLLI) sequence in CMRI: influence of contrast agent on absolute T1 values and the partition coefficient

Wednesday, October 26, 2011 — Poster Session III
10:00 a.m. – Noon	Natcher Conference Center	CC	IMAG-16

Authors

• N Kawel
• M Nacif
• F Santini
• S Liu
• J Bremerich
• A Arai
• D Bluemke

Abstract

Purpose: To evaluate the influence of contrast agents with different relaxivity on myocardial T1 values and the partition coefficient (λ) by using a Modified Look-Locker Inversion Recovery (MOLLI) sequence in cardiac MR. Materials and Methods: MOLLI was acquired in 20 healthy subjects (1.5T) at mid-ventricular short axis pre contrast and 5, 10, 20, 25, and 30 min after administration of a bolus of 0.15mmol/kg Gadolinium-BOPTA (n=10) or Gadolinium-DTPA (n=10). T1 times were measured in myocardium and blood pool. λ was approximated by ΔR1myocardium /ΔR1blood. Values for Gadolinium-BOPTA and Gadolinium-DTPA were compared. Inter-reader agreement was evaluated. Results: Absolute T1 times of myocardium and blood pool (p<0.001) and λ (0.42±0.03 and 0.47±0.04, respectively, p<0.001; excluding 5 min for Gadolinium-BOPTA) were significantly lower for Gadolinium-BOPTA than Gadolinium-DTPA. λ showed no significant variation between 5 and 30min for Gadolinium-DTPA. Gadolinium-BOPTA λ values were significantly lower at 5min compared to other times (0.38 vs. 0.42; p<0.05). Inter-reader agreement for λ values was excellent with Gadolinium-BOPTA and good for Gadolinium-DTPA. Conclusion: Absolute T1 and λ values are significantly lower for Gadolinium-BOPTA compared to Gadolinium-DTPA at the same administered dose. Using Gadolinium-BOPTA, the equilibrium between myocardium and blood pool is not achieved until 10min post contrast.

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