October 24 - 28, 2011
Building 10 & Natcher Conference Center
- General Schedule of Events
- Opening Plenary Session
- Concurrent Symposia Sessions
- Improving Workplace Dynamics
- FARE Award Ceremony
- Poster Sessions
- Special Exhibits on Resources for Intramural Research
- TSA Research Festival Exhibit Show
- Research Festival Committees
- Past Research Festivals
2011 program
Download the 2011 Research Festival Program Book
PDF documents require the free Adobe Reader
PA1 controls the induction of early adipogenic transcription factors
| Tuesday, October 25, 2011 — Poster Session II | |||
|---|---|---|---|
Noon – 2:00 p.m. |
Natcher Conference Center |
NIDDK |
EPIGEN/TRANS/CHROM-7 |
Authors
- JE Lee
- YW Cho
- X Feng
- O Gavrilova
- V Sartorelli
- C Deng
- K Ge
Abstract
Transcription factors Krox20, KLF4, C/EBP beta and C/EBP delta are induced within hours after induction of adipogenesis and are required for adipogenesis. However, the factors that control the induction of these early adipogenic transcription factors remain unclear. Here we show PTIP-associated 1 protein (PA1) controls the induction of Krox20, KLF4, C/EBP beta and C/EBP delta in the early phase of adipogenesis. Within hours after induction of adipogenesis, PA1 is recruited to Krox20, KLF4, C/EBP beta and C/EBP delta promoters, which correlates with the robust induction of these genes. Deletion of PA1 in preadipocytes prevents induction of these early adipogenic transcription factors and leads to severe defects in adipogenesis. PA1 facilitates CREB-mediated induction of KLF4 and C/EBP beta and glucocorticoid receptor (GR)-mediated induction of Krox20 and C/EBP delta. Finally, deletion of PA1 in white and brown adipose tissues significantly reduces tissue weight. Thus, by regulating the induction of early adipogenic transcription factors, PA1 plays a critical role in adipogenesis.
