Pre-existing kidney disorders and risk of renal cell carcinoma: results from a population-based case-control study of Caucasians and African Americans

Tuesday, October 25, 2011 — Poster Session II
Noon – 2:00 p.m.	Natcher Conference Center	NCI	EPID-8

* FARE Award Winner

Authors

• JN Hofmann
• K Schwartz
• WH Chow
• FG Davis
• JJ Ruterbusch
• N Rothman
• S Wacholder
• BI Graubard
• JS Colt
• MP Purdue

Abstract

Background: In the United States, the incidence of renal cell carcinoma (RCC) is higher among African Americans (AA) than among Caucasians. The etiology of RCC is unclear, though previous observations suggest that risk is elevated among patients with end-stage renal disease. Methods: We investigated RCC risk in relation to pre-existing kidney disorders in a population-based case-control study (1,217 cases, 1,235 controls). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression. Results: RCC risk was increased among subjects previously diagnosed with chronic renal failure (OR 4.7, 95% CI 2.2-10.1) or on dialysis (OR 18.0, 95% CI 3.6-91.1). Stronger associations were observed with longer duration of renal failure/dialysis (≥10y) prior to RCC diagnosis. The association between chronic renal failure and RCC was stronger among AAs than among Caucasians (ORs of 8.7 and 2.0, respectively; P-interaction=0.03). Among AAs, kidney stones, kidney cysts, and nephrotic syndrome were associated with a non-significant increased risk of RCC. Conclusions: The results of this population-based study suggest that chronic renal failure and dialysis may be important risk factors for RCC development in both AAs and Caucasians. Findings of differences in risk estimates by race, to our knowledge the first such report, require replication.

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