Genetic polymorphisms in candidate inflammation-related genes and risk of esophageal squamous cell carcinoma

Tuesday, October 25, 2011 — Poster Session II
Noon – 2:00 p.m.	Natcher Conference Center	NCI	EPID-7

Authors

• A Golozar
• I Ruczinski
• P Gravitt
• T Beaty
• N Hu
• YL Qiao
• JH Fan
• T Ding
• ZZ Tang
• S Dawsey
• N Freedman
• C Abnet
• A Goldstein
• P Taylor

Abstract

This study sought to assess the role of common genetic polymorphisms in 14 inflammation-related genes in the etiology of esophageal squamous cell carcinoma (ESCC). We used data from the Nutritional Intervention Trial (NIT) cohort and the Shanxi Case-Control Study, both conducted in northcentral China between 1985-2005. 410 ESCC cases and 377 controls from the NIT and 546 cases and 556 individually matched controls from Shanxi were genotyped for 189 tag single nucleotide polymorphisms (SNP)s. Tag SNPs were located within the 20 kb upstream and 10 kb downstream of each gene with an r2≥0.8 and minor allele frequency of ≥5%. Cox proportional-hazard models with robust variance estimator and conditional logistic regression models were used for individual SNP analyses for the NIT and Shanxi, respectively. Fisher’s Combination method was then used to obtain gene-level p-values. Significance of the findings was assessed empirically using 5000 permutations. Although several SNPs showed nominal significance in both studies, none retained permutation statistical significance. At the gene level, vascular endothelial growth factor A (VEGFA) yielded a permutation level significance of 0.023 only in the NIT. The results of this study provide little evidence for the role of the 14 inflammation-related genes in the etiology of ESCC.

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