Dietary factors and risk of bladder cancer in the New England region of the United States

Tuesday, October 25, 2011 — Poster Session II
Noon – 2:00 p.m.	Natcher Conference Center	NCI	EPID-15

Authors

• J Wu
• A Cross
• D Baris
• D Silverman
• M Ward
• M Karagas
• A Johnson
• S Cherala
• M Schewnn
• J Colt
• K Cantor
• N Rothman
• R Sinha

Abstract

Background: Despite many studies on diet and bladder cancer, there are inconsistencies and gaps in our understanding. Methods: We conducted a population-based case-control study that recruited participants from Maine, New Hampshire, and Vermont from 2001-2004. Cases (n=1,068) were ascertained through hospital pathology records and cancer registries. Controls (n=1,266) were identified via the Department of Motor Vehicles and Center for Medicaid and Medicare Services. Cases and controls were frequency matched by state, sex, and age. Usual diet was self-reported using a food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by unconditional logistic regression for a range of foods and nutrients in relation to bladder cancer. Results: Processed meat intake was positively associated with bladder cancer (OR for the highest versus lowest intake quartile: 1.29; 95% CI: 1.00-1.66; p-trend=0.03); this association was stronger for processed red meat (OR: 1.42; 95% CI: 1.09-1.86; p-trend=0.02). In contrast, vitamin B12 was inversely associated with bladder cancer (OR: 0.77; 95% CI: 0.61-0.98; p=0.02). Conclusion: Processed meat intake has been implicated in carcinogenesis at a variety of anatomic sites; our study suggests that this may include the bladder. The inverse association for vitamin B12 and bladder cancer should be further explored.

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