Common genetic variants in the 8q24 region and risk of papillary thyroid cancer

Tuesday, October 25, 2011 — Poster Session II
Noon – 2:00 p.m.	Natcher Conference Center	NCI	EPID-12

* FARE Award Winner

Authors

• G Neta
• C-L Yu
• A Brenner
• F Gu
• A Hutchinson
• R Pfeiffer
• E Sturgis
• L Xu
• M Linet
• B Alexander
• S Chanock
• A Sigurdson

Abstract

Background: Single nucleotide polymorphisms (SNPs) in the 8q24 chromosomal region identified from genome-wide scans have been associated with several cancers including breast (rs1562430), prostate and colon (rs1447295 and rs6983267) cancers. A genome-wide scan in 26 families with papillary thyroid cancer (PTC) also found susceptibility loci in 8q24, supporting a closer evaluation of the chromosomal region for risk of sporadic PTC. Methods: We evaluated 157 tag single nucleotide polymorphisms (SNPs), including rs1562430, rs1447295, and rs6983267, in the 8q24 chromosomal region in a case-control study of 344 papillary thyroid cancer (PTC) cases and 452 age and gender frequency matched controls. We estimated p-values for associations of individual tag SNPs with PTC risk. Results: We did not find an association between rs1562430, rs1447295, or rs6983267, and sporadic PTC risk. We found one tag SNPs (rs4733616) was associated with PTC risk at P < 0.01, and twelve other SNPs were associated with PTC risk at P < 0.05. However, no SNPs were significant after multiple comparisons adjustment. Conclusions: Our study does not provide strong evidence for an association between common genetic variants in the 8q24 chromosomal region and PTC risk.

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