Experience with a patient-friendly, mandatory single blastocyst transfer policy: the power of one

Wednesday, October 26, 2011 — Poster Session III
10:00 a.m. – Noon	Natcher Conference Center	NICHD	CLIN/CULT/AGING/DISPREV-9

Authors

• M Hill
• J Csokmay
• R Chason
• J Cohen
• A DeCherney
• J Segars
• A James
• M Payson

Abstract

Objective: To retrospectively evaluate a mandatory single blastocyst transfer (mSBT) algorithm. Materials and Methods: A mSBT was implemented at the start of 2010. All patients < 38 years old undergoing their first ART cycle in 2009-2010 with ≥ 4 high grade embryos on post-oocyte retrieval day 3 were included. On post oocyte retrieval day 5, patients were transferred a single high grade blastocyst. If the blastocyst was not high grade, the option to transfer 1 or 2 blastocysts was given. Patients from 2009 constituted the “before” group and the “after” group consisted of patients who completed ART under the mSBT policy in 2010. Primary outcome measures were multiple gestations and clinical pregnancy rates. Results: 136 patients met inclusion criteria. Baseline demographics were similar between the groups. There was a reduction in blastocysts transferred per patient from 2009 to 2010 (1.9 vs. 1.5, p<0.001). Clinical pregnancy rates before and after the mSBT policy were not different (67.7% vs. 63.5%, p=0.61). Multiple gestation rates were reduced by 67% after the mSBT policy was instituted (43.8% vs. 14.6%, p=0.001). Conclusions: This novel single blastocyst transfer algorithm reduced multiple gestation rates and improved cryopreservation rates without compromising clinical pregnancy rates in good prognosis patients.

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