GEO database: new developments and tools for data query and analysis

Monday, October 24, 2011 — Poster Session I
Noon – 2:00 p.m.	Natcher Conference Center	NLM	BIOINFO-7

Authors

• M Holko
• K Ayanbule
• C Evangelista
• I Kim
• H Lee
• P Ledoux
• K Marshall
• R Muertter
• K Phillippy
• P Sherman
• A Soboleva
• M Tomashevsky
• S Wilhite
• A Yefanov
• T Barrett

Abstract

The Gene Expression Omnibus (GEO) at the National Center for Biotechnology Information (NCBI) is the world's largest open repository and distribution hub for functional genomic data generated by microarray and next-generation sequence technologies. GEO currently holds over 20,000 studies encompassing half a million samples, spanning over 1,500 organisms, and addressing a huge variety of biological phenomena. These data have been deposited by over 10,000 researchers from around the world. To maximize the utility of these data, we have developed a collection of Web-based interfaces and tools to help researchers effectively query, visualize, analyze, and download GEO data. These tools do not require specialized knowledge of microarray analysis methods, nor do they require time-consuming download of large data sets. Data may be queried and visualized from both experiment- and gene-centric perspectives. GEO data are also richly interconnected with other NCBI databases including Gene, GenBank, and PubMed, adding further value to the data and providing opportunity to discover previously unidentified relationships between diverse data types. Many research groups use GEO data to supplement their own studies and for the discovery of novel findings. In this poster, we introduce new tools to facilitate the query and analysis of GEO data.

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