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ISRCE at ABCC: non-B DNA and cancer

Monday, October 24, 2011 — Poster Session I

Noon – 2:00 p.m.

Natcher Conference Center




  • D Donohue
  • N Temiz
  • A Bacolla
  • R Cer
  • K Bruce
  • U Mudunuri
  • M Yi
  • N Volfovsky
  • B Luke
  • R Stephens
  • J Collins


As one of five NIH In Silico Research Centers of Excellence (ISRCE), the Advanced Biomedical Computing Center (ABCC) at SAIC-Frederick works with the caBIG project to investigate the role on non-B DNA in cancer. Non-canonical DNA structures such as Z-DNA, G-quadruplexes, triplex DNA, cruciforms, A-phased DNA, and slipped DNA. Our new non-B Database (nonB-DB, freely available at catalogues the location of these motifs and other genomic annotations in several mammalian reference genomes. Additional user specific sequences can be analyzed using the accompanying non-B DNA Motif Search Tool (nBMST, We are running molecular dynamics simulations of non-B DNA to determine which sequences and conditions are most likely to promote their formation.

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