October 24 - 28, 2011
Building 10 & Natcher Conference Center
- General Schedule of Events
- Opening Plenary Session
- Concurrent Symposia Sessions
- Improving Workplace Dynamics
- FARE Award Ceremony
- Poster Sessions
- Special Exhibits on Resources for Intramural Research
- TSA Research Festival Exhibit Show
- Research Festival Committees
- Past Research Festivals
2011 program
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ISRCE at ABCC: non-B DNA and cancer
| Monday, October 24, 2011 — Poster Session I | |||
|---|---|---|---|
Noon – 2:00 p.m. |
Natcher Conference Center |
NCI |
BIOINFO-6 |
Authors
- D Donohue
- N Temiz
- A Bacolla
- R Cer
- K Bruce
- U Mudunuri
- M Yi
- N Volfovsky
- B Luke
- R Stephens
- J Collins
Abstract
As one of five NIH In Silico Research Centers of Excellence (ISRCE), the Advanced Biomedical Computing Center (ABCC) at SAIC-Frederick works with the caBIG project to investigate the role on non-B DNA in cancer. Non-canonical DNA structures such as Z-DNA, G-quadruplexes, triplex DNA, cruciforms, A-phased DNA, and slipped DNA. Our new non-B Database (nonB-DB, freely available at http://nonb.abcc.ncifcrf.gov/) catalogues the location of these motifs and other genomic annotations in several mammalian reference genomes. Additional user specific sequences can be analyzed using the accompanying non-B DNA Motif Search Tool (nBMST, http://nonb.abcc.ncifcrf.gov/apps/nBMST/). We are running molecular dynamics simulations of non-B DNA to determine which sequences and conditions are most likely to promote their formation.
