The Hemagglutinin Structure Prediction (HASP) project: an interactive tool for the generation and analysis of high-quality hemagglutinin homology model

Monday, October 24, 2011 — Poster Session I
Noon – 2:00 p.m.	Natcher Conference Center	NIAID	BIOINFO-5

Authors

• J Dommer
• X Ambroggio
• V Gopalan
• E Dunham
• J Taubenberger
• D Hurt

Abstract

The Hemagglutinin Structure Prediction (HASP) project is an online resource for the VPES, the NIAID, and the greater scientific community providing high-quality homology models built using Rosetta for all publicly available hemagglutinin (HA) protein sequences. HASP presents the models in such a way that researchers can gain scientific insights directly through the application and can easily retrieve the structures for more intensive offline studies and analysis. The HASP server was designed as a scientific tool for researchers to visualize their phylogenetic, biochemical, and immunological HA data in the three-dimensional context of the HA structure. HASP allows researchers to search the models by keyword in a variety of categories, such as year of strain isolation, geographical location of strain isolation, known host species, and strain type. Two models selected by the researcher can be displayed directly in a built-in Jmol viewer, allowing for toggling between viewing the structures superposed onto each other or side-by-side. The viewer also provides an alignment of user-selected hemagglutinin sequences with the ability to highlight residues with a mouse-click on both the sequence and the structure viewer. This feature allows the researcher to rapidly identify points of interest.

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