Variable cellular conduct of photonic nano-dots

Monday, October 24, 2011 — Poster Session I
Noon – 2:00 p.m.	Natcher Conference Center	NIBIB	BIOCHEM/CHEM-3

Authors

• A Bhirde
• Y Sun
• X Chen

Abstract

Quantum dots (Qdots) have made a great impact in the field of biomedical optical imaging. Recently the smaller Qdots (< 10 nm) have shown greater impact in cellular imaging, however the metal content in their formulation has hindered its progress towards translational venue. Carbon dots (Cdots) are novel carbon based nanoparticles which have shown promise as replacements for the conventional Qdots. Cdots are equally photo-stable and are less than 10 nm in size. However not much is known about their cellular uptake and in vivo imaging applicability. Herein we show their cellular uptake in various cell type using both confocal and two-photon fluorescence imaging. Toxicity of Cdots on various cell types is also studied here. Cdots have the potential to impact in both health and environmental applications because of their low cost, ready scalability, excellent chemical stability, biocompatibility, colloidal stability, and resilience of PL in vivo.

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