October 24 - 28, 2011
Building 10 & Natcher Conference Center
- General Schedule of Events
- Opening Plenary Session
- Concurrent Symposia Sessions
- Improving Workplace Dynamics
- FARE Award Ceremony
- Poster Sessions
- Special Exhibits on Resources for Intramural Research
- TSA Research Festival Exhibit Show
- Research Festival Committees
- Past Research Festivals
2011 program
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Synthesis of glycopeptides: coupling efficiency vs. epimerization
| Monday, October 24, 2011 — Poster Session I | |||
|---|---|---|---|
Noon – 2:00 p.m. |
Natcher Conference Center |
NCI |
BIOCHEM/CHEM-21 |
Authors
- S Muthana
- Y Zhang
- D Farnsworth
- J Gildersleeve
Abstract
Obtaining structurally-defined glycopeptides is very important to study their biological functions and to be utilized for clinical applications. In this work we carried out a systematic comparison of published coupling conditions toward our effort to identify the optimal conditions for preparing glycopeptides. We looked at the coupling of four Fmoc-protected glyco-amino acids and their non-glycoslyated counterpart. We found that epimerization is more of a problem than the coupling efficiency of glyco-amino acids.
