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Synthesis of glycopeptides: coupling efficiency vs. epimerization

Monday, October 24, 2011 — Poster Session I

Noon – 2:00 p.m.

Natcher Conference Center




  • S Muthana
  • Y Zhang
  • D Farnsworth
  • J Gildersleeve


Obtaining structurally-defined glycopeptides is very important to study their biological functions and to be utilized for clinical applications. In this work we carried out a systematic comparison of published coupling conditions toward our effort to identify the optimal conditions for preparing glycopeptides. We looked at the coupling of four Fmoc-protected glyco-amino acids and their non-glycoslyated counterpart. We found that epimerization is more of a problem than the coupling efficiency of glyco-amino acids.

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