Genomics of cardiovascular disease and its risk factors: From discovery to biology to the clinic

Wednesday, November 06, 2013 — Concurrent Symposia Session I
12:30 p.m. – 2:30 p.m.	FAES Academic Center lower-level Classrooms 1 and 2

Co-chairs

Christopher O'Donnell, NHLBI
Les Biesecker, NHGRI

Program

Cardiovascular disease is the leading cause of death in men and women. Genome-wide studies have yielded a remarkable harvest of discoveries regarding the role of gene variants in cardiovascular disease and its risk factors. Ongoing research is focused on the role of common, rare and private variants in the etiology of disease, as well as discovery of the biological mechanisms underlying disease associations and translation into clinical and population applications. This symposium highlights ongoing progress, opportunities and challenges, and next steps for investigators in the NIH DIR in the genomics of cardiovascular disease and its risk factors. The speakers in this symposium will focus on latest developments in the genetic and genomic epidemiology of cardiovascular disease and its risk factors. Dr. Gary Gibbons, Director of the National Heart, Lung, and Blood Institute will give brief remarks during the symposium as well.

Genomics of cardiovascular disease introductory Overview
Christopher O'Donnell, NHLBI

Investigation of gene-diet interaction on cardiovascular disease risk factors
Toshiko Tanaka, NIA

Genetic factors of gestational diabetes relevant to type 2 diabetes and comorbidities
Cuilin Zhang, NICHD

Trans-ethnic fine mapping of white blood cell phenotypes
Margaux Keller, NIA

Understanding CXCL12: An inflammatory chemokine discovered by GWAS of myocardial infarction
Nehal Mehta, NHLBI

FARE Award Winners
Shurjo Sen (NHGRI) and Sara Menazza, NHLBI