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The chemical biology of nucleic acid synthesis, modification, and detection

Friday, November 08, 2013 — Concurrent Symposia Session IV

12:00 p.m. – 2:00 p.m.

FAES Academic Center lower-level Classroom 4


  • Daniel Appella, NIDDK


Studying, altering, and detecting nucleic acids are fundamental areas of research across the fields of chemistry, biology, and medicine. Many diseases and pathogens have a genetic signature that can serve as a marker for a specific illness. New approaches to detect nucleic acids will be presented in the first part of the symposium. Nucleic acids may also be considered as targets for drugs or used components of a therapy. The last part of the symposium will discuss approaches in this area.

Gold nanoparticle microarray detection of influenza viruses
Indira Hewlett, FDA/CBER

Low level HIV detection during antiretroviral therapy: Current concepts and controversies
Frank Maldarelli, NCI

Chemical strategies to facilitate peptide nucleic acid detection of HIV RNA
Daniel Appella, NIDDK

G-quadruplex-based strategies to target DNA with peptide nucleic acids
Igor Panyutin, CC

Targeting and delivering nucleic acids for the treatment of rare genetic diseases
Philip Brooks, NCATS

Deciphering the role of APE1 protein variants in disease etiology; FARE Award Winner
Jennifer Illuzzi, NIA

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