Epigenetic regulation and chromosome transmission in health and disease

Wednesday, November 06, 2013 — Concurrent Symposia Session I
12:30 p.m. – 2:30 p.m.	Masur Auditorium

Chair

Mirit Aladjem, NCI

Program

Healthy growth depends on precise and well-regulated cell divisions, insuring that all the genetic and epigenetic information stored in parent cells’ chromosomes is transferred faithfully to the next generation. Inaccurate or incomplete transmission of information during cell divisions can cause developmental errors, facilitate malignancy and associate with age-related pathologies. Recent studies have indicated that epigenetic modifications, which affect chromatin packaging, critically regulate chromosome transmission to daughter cells during cell division as well as chromosome structure and gene expression. This symposium will highlight recent progress in understanding how epigenetic modifications and regulation of chromosome transmission control genomic stability in normal and malignant cells.

Should I stay or should I go? How cells know when to release the spindle checkpoint break
Mary Dasso, NICHD

Epigenetic regulation of photoreceptor-specific gene expression
Hyun-Jin Yang, NEI

Deacetylase SIRT1 in epigenetic regulation
Chuxia Deng, NIDDK

Epigenetic regulation of DNA replication in mammalian cells
Mirit Aladjem, NCI

A mutant p53/let-7 axis regulated network controls proliferation and metastasis
Ashish Lal, NCI