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Molecular mechanisms of aging

Friday, November 08, 2013 — Concurrent Symposia Session IV

12:00 p.m. – 2:00 p.m.

Masur Auditorium


  • Francesca Macchiarini, NIAID
  • Ron Johnson, NCI


Thanks in large part to the success of NIH-supported research, the world population lives significantly longer today than 80 years ago when the NIH was created. However, longer life expectancy has resulted in a much higher incidence of cancer, cardiovascular diseases, Type 2 diabetes, Alzheimer’s disease, and chronic conditions like loss of immune responsiveness, osteoporosis, sarcopenia, and macular degeneration. These aging-related diseases and conditions have driven a substantial increase in medical care costs. A surge in the research focus on aging across all biomedical disciplines bodes well for a transition from basic research to therapeutic treatments of age-associated diseases. This symposium, “ Molecular mechanisms of aging” brings together a diverse group of speakers from multiple Institutes and Centers to showcase cutting edge intramural research on the molecular connections between aging, health, and disease.

Mechanisms for lifespan extension under calorie restriction in yeast
Jennifer Lippincott-Schwartz, NICHD

Chromatin condensation in DNA repair: Implications for (epi)genomic integrity
Philipp Oberdoerffer, NCI

Mitochondrial mitophagy and aging
Chiu-Hui Huang, NINDS

Reversing aging-related metabolic decline
Jay Chung, NHLBI

Forkhead box protein A3 deficient mice display an age associated lean phenotype and enhanced thermogenesis; FARE Award Winner
Lingyan Xu, NIDDK

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