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The role of proteostasis (protein homeostasis) in health and disease

Thursday, November 07, 2013 — Concurrent Symposia Session III

2:00 p.m. – 4:00 p.m.

FAES Academic Center lower-level Classroom 4


  • Andras Orosz, NIAAA
  • Jay Chung, NHLBI


Proteostasis (protein homeostasis) balance is essential for cellular and organismal health, fitness, adaptation to environmental challenges and ultimately, life. Derailed proteostasis leads to protein misfolding and aggregation that are implicated in many devastating human disorders including neurodegenerative diseases (e.g. Alzheimer’s, Parkinson’s), type 2 diabetes, cancer, cardiomyopathy, cystic fibrosis, cataract, prion disease, immune problems, metabolic deficiencies, and others. It is well established that proteostasis naturally declines during aging. While there has been a substantial effort to understand many of the individual components of proteostasis such as protein synthesis, folding, trafficking, and clearance, the underlying disease etiology of unbalanced proteostasis remains poorly understood. This symposium is aimed to provide critical insights about the role of the proteostasis network (PN) across all tissues during development and aging, in health and disease, and will address potential treatment modalities for a diverse array of chronic disorders with increasingly heavy burden on society.

The effect of obesity and aging on proteostasis
Jay Chung, NHLBI

Life and death in the inner ear: Heat shock proteins and sensory hair cells; Dr. Elyssa Monzack will replace Dr. Cunningham as the speaker.
Lisa Cunningham, NIDCD

Cbl family ubiquitin protein ligases, RTK signaling, and cancer
Stan Lipkowitz, NCI

Impact of energy metabolism on neuronal proteostasis
Mark Mattson, NIA

Prion sequestration by the Btn2 and Cur1 proteins; Dr. Daniel Masison will replace Dr. Wickner as the speaker. His title will be, "Yeast prions and protein chaperones"
Reed Wickner, NIDDK

A Caspase-8 dependent pathway for ER stress mediated IL-1beta maturation; FARE Award Winner
Nicolas Riteau, NIAID

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