October 7 - 11, 2013
Building 10
- General Schedule of Events
- Opening Plenary Session
- Concurrent Symposia Sessions
- Poster Sessions
- National Graduate Student Research Conference
- FARE Award Ceremony
- Special Exhibits on Resources for Intramural Research
- TSA Research Festival Exhibit Show
- Clinical Center Tours
- Research Festival Committees
- Past Research Festivals
The role of proteostasis (protein homeostasis) in health and disease
| Thursday, November 07, 2013 — Concurrent Symposia Session III | |
|---|---|
2:00 p.m. – 4:00 p.m. |
FAES Academic Center lower-level Classroom 4 |
Co-chairs
- Andras Orosz, NIAAA
- Jay Chung, NHLBI
Program
Proteostasis (protein homeostasis) balance is essential for cellular and organismal health, fitness, adaptation to environmental challenges and ultimately, life. Derailed proteostasis leads to protein misfolding and aggregation that are implicated in many devastating human disorders including neurodegenerative diseases (e.g. Alzheimer’s, Parkinson’s), type 2 diabetes, cancer, cardiomyopathy, cystic fibrosis, cataract, prion disease, immune problems, metabolic deficiencies, and others. It is well established that proteostasis naturally declines during aging. While there has been a substantial effort to understand many of the individual components of proteostasis such as protein synthesis, folding, trafficking, and clearance, the underlying disease etiology of unbalanced proteostasis remains poorly understood. This symposium is aimed to provide critical insights about the role of the proteostasis network (PN) across all tissues during development and aging, in health and disease, and will address potential treatment modalities for a diverse array of chronic disorders with increasingly heavy burden on society.
The effect of obesity and aging on proteostasisJay Chung, NHLBI
Life and death in the inner ear: Heat shock proteins and sensory hair cells; Dr. Elyssa Monzack will replace Dr. Cunningham as the speaker.
Lisa Cunningham, NIDCD
Cbl family ubiquitin protein ligases, RTK signaling, and cancer
Stan Lipkowitz, NCI
Impact of energy metabolism on neuronal proteostasis
Mark Mattson, NIA
Prion sequestration by the Btn2 and Cur1 proteins; Dr. Daniel Masison will replace Dr. Wickner as the speaker. His title will be, "Yeast prions and protein chaperones"
Reed Wickner, NIDDK
A Caspase-8 dependent pathway for ER stress mediated IL-1beta maturation; FARE Award Winner
Nicolas Riteau, NIAID
