Genes and pathway discovery in the context of human disease

Thursday, November 07, 2013 — Concurrent Symposia Session III
2:00 p.m. – 4:00 p.m.	Masur Auditorium

Co-chairs

Scott Martin, NCATS
Natasha Caplen, NCI

Program

Gene silencing through RNA interference (RNAi) has become a staple tool for understanding gene function. Over the past decade, high-throughput RNAi screens have illuminated a wide variety of biology. These studies have also illustrated many of the pitfalls undermining the successful application of RNAi. This symposium will begin with a discussion of these pitfalls along with tools used to improve success in RNAi screens and then transition towards highlighting exciting discoveries made by NIH researchers in collaboration with the Trans-NIH RNAi Screening Facility at NCATS. A special emphasis will be placed on genes and pathways associated human disease.

RNAi screening version 2.0. This time, it's not a false positive.
Gene Buehler, NCATS

Genome-wide siRNA screening identifies genes involved in Parkin-mediated mitochondria quality control
Lesley Kane, NINDS

A novel method for assessing malaria risk reveals a correlation between Plasmodium falciparum RH5-specific IgG and protection from malaria
Tuan Tran, NIAID

A Genome-wide RNAi screen identifies novel modifiers of survival motor neuron (SMN) levels via altered RNA splicing and enhanced protein stability
Barrington Burnett, NINDS

Identifying miRNA and their targets responsible for the cisplatin-resistance phenotype
Matthew Hall, NCI