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Structural Informatics of influenza hemagglutinin antibody engagement.

Friday, November 08, 2013 — Poster Session IV

2:00 p.m. – 4:00 p.m.

FAES Academic Center (Upper-Level Terrace)




  • DM McCraw
  • AK Harris


Hemagglutinin (HA) is the major surface glycoprotein to which neutralizing antibodies are elicited for Influenza virus. Neutralizing epitopes reside in both the head region composed of HA1 globular domains and the stem region composed of HA2 domains. Highly conserved epitopes within the stem region of HA2 are the targets of a number of broadly neutralizing antibodies and hold promise for the design a universal influenza vaccine. However, it is still unclear what strategies will prove successful in engineering a vaccine that promotes broadly neutralizing antibodies to conserved HA epitopes. Here, we used structural informatics approaches in which we combined structural, biochemical, and immunological analyses in order to understand HA antigen-antibody interactions and we identified factors that influence hemagglutinin-antibody engagement.

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