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The Bench-to-Bedside (B2B) Program: Connecting the Clinical Center’s past and future

Thursday, November 07, 2013 — Poster Session II

12:00 p.m. – 2:00 p.m.

FAES Academic Center (Upper-Level Terrace)




  • C.D. Bell
  • H. Haleem-Smith
  • P.I. Piringer


Since opening in 1953, the Clinical Center (CC) has epitomized the “bench-to-bedside” philosophy to expedite translation of basic scientific findings into therapies. In 1999, the CC introduced the Bench-to-Bedside (B2B) Program to create another incentive for intramural basic researchers to engage in translational research with their clinical colleagues. The B2B program provided a mechanism for basic and clinical scientists across different institutes to pursue an innovative, small-scale translational project. In 2006, in addition to overcoming silos between basic and clinical scientists and between intramural programs, B2B also overcame another barrier to translational research when the program invited applications from intramural-extramural teams. The outside community’s response has been strong; between 2006 and 2012, ~90% of applications involved an extramural investigator as a research partner. The program is an excellent example of basic-clinical and intramural-extramural partnerships, and served as the model for a new trans-NIH grant mechanism, “Opportunities for Collaborative Research at the NIH Clinical Center (U01).” The $45 million in B2B funds awarded over the past 14 years have fostered partnerships and research discoveries and via the new U01 program, has enhanced the opportunities available for outside investigators to access Clinical Center resources.

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