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The Neurotherapeutics Development Unit of NINDS Translational Neuroscience Center: Core activities

Thursday, November 07, 2013 — Poster Session II

12:00 p.m. – 2:00 p.m.

FAES Academic Center (Upper-Level Terrace)




  • J. P. Steiner
  • M. Bachani
  • K. Mather
  • M. J. Vaal
  • R. Babu
  • A. Nath


The Neurotherapeutics Development Unit (NTDU) of the NINDS Translational Neuroscience Center focuses on preclinical development of neuroprotective and neuroregenerative agents. We work collaboratively with other NIH researchers to facilitate therapeutics development for neurodegenerative disorders. Our approach is to develop and utilize medium-high throughput cell based assays for identifying novel therapeutic compounds. We develop and conduct screening assays for neuroprotection in rat mixed cortical/hippocampal neurons and human neural stem cell (NSC)-derived neurons and astrocytes, using our automated cell-based assay system. We utilize high content imaging of these rat and human neuronal cultures to quantitate neurotrophic potential of the therapeutic agents. We characterize the cellular and biopharmaceutical properties of potential neuroprotective and neuroregenerative compounds to demonstrate efficacy in vitro and in vivo. Ultimately, the core activity of the NTDU is to facilitate preclinical development of potential therapeutic agents, identified internally at NINDS/NIH and by external investigators. We will utilize medicinal chemistry, neuronal cell biology, molecular biology, pharmacology, biochemistry and biopharmaceutics techniques to achieve these goals.

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