October 9 - 12, 2012
Building 10 & Natcher Conference Center
- General Schedule of Events
- Opening Plenary Session
- Concurrent Symposia Sessions
- Poster Sessions
- National Graduate Student Research Conference
- FARE Award Ceremony
- Special Exhibits on Resources for Intramural Research
- TSA Research Festival Exhibit Show
- Clinical Center Tours
- Research Festival Committees
- Past Research Festivals
The Neurotherapeutics Development Unit of NINDS Translational Neuroscience Center: Core activities
| Thursday, November 07, 2013 — Poster Session II | |||
|---|---|---|---|
12:00 p.m. – 2:00 p.m. |
FAES Academic Center (Upper-Level Terrace) |
NINDS |
RSCHSUPP-33 |
Authors
- J. P. Steiner
- M. Bachani
- K. Mather
- M. J. Vaal
- R. Babu
- A. Nath
Abstract
The Neurotherapeutics Development Unit (NTDU) of the NINDS Translational Neuroscience Center focuses on preclinical development of neuroprotective and neuroregenerative agents. We work collaboratively with other NIH researchers to facilitate therapeutics development for neurodegenerative disorders. Our approach is to develop and utilize medium-high throughput cell based assays for identifying novel therapeutic compounds. We develop and conduct screening assays for neuroprotection in rat mixed cortical/hippocampal neurons and human neural stem cell (NSC)-derived neurons and astrocytes, using our automated cell-based assay system. We utilize high content imaging of these rat and human neuronal cultures to quantitate neurotrophic potential of the therapeutic agents. We characterize the cellular and biopharmaceutical properties of potential neuroprotective and neuroregenerative compounds to demonstrate efficacy in vitro and in vivo. Ultimately, the core activity of the NTDU is to facilitate preclinical development of potential therapeutic agents, identified internally at NINDS/NIH and by external investigators. We will utilize medicinal chemistry, neuronal cell biology, molecular biology, pharmacology, biochemistry and biopharmaceutics techniques to achieve these goals.
