Small Animal Imaging Program (SAIP), Frederick National Laboratory for Cancer Research

Thursday, November 07, 2013 — Poster Session II
12:00 p.m. – 2:00 p.m.	FAES Academic Center (Upper-Level Terrace)	NCI	RSCHSUPP-18

Authors

J.D. Kalen
M. Bernardo
P.L. Choyke
P.Z. Grodzinski
L.V. Ileva
K.L. Komschlies
N. Patel
L.A. Riffle
J.L. Tatum

Abstract

The Small Animal Imaging Program (SAIP), a program within the Laboratory Animal Sciences Program Directorate (LASP), Frederick National Laboratory for Cancer Research, provides comprehensive state-of-the-art in vivo imaging techniques to assist researchers to investigate intact complex biological systems; characterize mouse models and molecular imaging probes for early detection and therapy, imaging disease-related biomarkers and pathways, monitor tumors in vivo, and serial imaging for pre-clinical drug efficacy studies. The SAIP imaging facility (> 7,500 square feet) incorporates several pre-clinical non-invasive in vivo modalities and capabilities: [bioluminescence, fluorescence, 3D-tomographic fluorescence, 3.0T MRI utilizing specially designed rodent coils, X-ray computed tomography (CT), single photon emission computed tomography (SPECT/CT), ultrasound with photoacoustic option, and positron emission tomography (PET/CT)], web based image archival system, high-end image processing work-stations, several animal holding rooms, laboratories for surgery and cell work, access to expert veterinary care (Laboratory Animal Medicine/LASP), correlation to ex vivo pathological results (PHL/LASP), image visualization development (IVG/ABCC), and animal models (Transgenic Mouse Model Laboratory/LASP). The SAIP provides quantitative analysis of numerous anatomical, physiological and functional parameters including; tumor perfusion, glucose metabolism, tumor permeability, cardiac function, tracer kinetics and biodistribution, cell proliferation, blood flow and volume, and oxygen saturation.