Skip to main content

Spatial Distribution of Brain Microhemorrhage Resulting from Traumatic Brain Injury (TBI)

Wednesday, November 06, 2013 — Poster Session I

4:00 p.m. – 6:00 p.m.

FAES Academic Center (Upper-Level Terrace)




  • N Li
  • Y Chou
  • D Joy
  • L Chan
  • DL Pham
  • JA Butman


This study examines the spatial distribution of microbleeds in a series of 46 sequential patients enrolled in a natural history study of TBI. SWI (TE=25ms, FA=20°, 0.49×0.49×2.0 mm) and 3D T1-MPRAGE images were acquired on a 3T Siemens Biograph mMR. Images were reviewed by a neuroradiologist on a Carestream PACS workstation, and microbleeds were labeled using the “marker” graphic tool. A total of 629 microbleeds were identified. An average of 13±34 (range=1-179) microbleeds were identified in the 24 positive patients. To characterize the distribution in standard MNI space, the T1-MPRAGE was affine registered to the MNI template. This transformation was applied to the co-registered SWI and the markers. Microbleeds congregated around the periphery of the brain and were symmetrically distributed, although a number were found in the corpus callosum. Using Talairach ROI analysis, microbleeds were most prevalent in the frontal lobes (59.9%). The lobar distribution was temporal: 10.1%, parietal 1.3%, occipital: 4.7%, limbic: 3.6%. Sublobar distribution was brainstem: 1.4%, cerebellum: 4.8%, deep cerebral white matter (WM): 6.8%, thalamus and basal ganglia: 1.3%. Future work will expand the analysis to additional subjects and more detailed regions such as WM tracts, as well as examine distribution differences between impact and blast injuries.

back to top