October 9 - 12, 2012
Building 10 & Natcher Conference Center
- General Schedule of Events
- Opening Plenary Session
- Concurrent Symposia Sessions
- Poster Sessions
- National Graduate Student Research Conference
- FARE Award Ceremony
- Special Exhibits on Resources for Intramural Research
- TSA Research Festival Exhibit Show
- Clinical Center Tours
- Research Festival Committees
- Past Research Festivals
Effects of a D2R antagonist on changes in cross-frequency power coupling related to the trade-off between attention demanding and automatic processes in frontal-striatal circuits
| Wednesday, November 06, 2013 — Poster Session I | |||
|---|---|---|---|
4:00 p.m. – 6:00 p.m. |
FAES Academic Center (Upper-Level Terrace) |
NIMH |
NEURO-19 |
Authors
- E. Lee
- S. Moon
- O. Dal Monte
- B.B. Averbeck
Abstract
Emerging research suggests that frontal-striatal circuits are involved in the trade-off between attention demanding and automatic processes. However, the role of dopamine in frontal-striatal interactions and the implications for this trade-off has not been examined directly. To investigate this, we trained monkeys on an oculomotor sequential decision making task with two conditions: a random condition (attention demanding) and a fixed condition (automatic). While the monkeys performed the task, we injected locally a dopamine D2R antagonist or saline into the dorsal striatum (dStr) bilaterally. In addition to the injections, we recorded local field potentials from lateral prefrontal cortex (lPFC) and dStr simultaneously. Behavioral results showed that the D2R antagonist affected performance in the fixed condition only compared with the random condition and the saline sessions. Moreover, we examined changes in cross-frequency power coupling between pre- and post-drug (saline) injections within each session. Overall, our results suggest that the indirect pathway through the basal ganglia, which contains primarily D2Rs, modulates the transition between attention demanding and automatic processes. Furthermore, the effects of antagonist injections on the linear and nonlinear interactions within dStr and between lPFC-dStr in 8-30 hz range suggest an important role for dopamine in the trade-off between the two processes.
