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Lack of close similarity between the Noble rat and common inbred laboratory rat strains

Friday, November 08, 2013 — Poster Session III

10:00 a.m. – 12:00 p.m.

FAES Academic Center (Upper-Level Terrace)




  • J.A. Lautenberger
  • R.C. Johnson
  • C.E. McIntosh
  • G.W. Nelson
  • Y. Yang
  • A.O. Perantoni


Wilms’ tumor or nephroblastoma is an important pediatric cancer with an incidence of about 1 in 10,000 children. The inbred Noble (Nb) strain of the laboratory rat Rattus norvegicus serves an experimental model for this tumor since it is susceptible to a low incidence of spontaneous nephroblastoma, and transplancental exposure to N-nitrosoethylurea (ENU) can induce this tumor in about 50% of treated animals. In contrast, inbred F344/NCr rats are completely resistant to nephroblastoma induction. The genotypes for SNPs that were found to be fixed in four Nb rat samples were compared to the genotypes for these SNPs in 142 substrains from 87 distinct inbred rat strains. The maximum level of SNP agreement between Nb and the other rats was about 75% with approximately the same level of agreement with most clusters of rats in a published phylogenetic tree. The lowest SNP agreement was with the BN rat. This analysis shows that no rats from a rather comprehensive set of common inbred strains can be regarded as a very close relative to the Noble rat in comparative studies.

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