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Occupational Trichloroethylene Exposure and Risk of Lymphatic and Hematopoietic Cancers: A Meta-Analysis

Thursday, November 07, 2013 — Poster Session II

12:00 p.m. – 2:00 p.m.

FAES Academic Center (Upper-Level Terrace)




  • S Karami
  • B Bassig
  • PA Stewart
  • K-M Lee
  • N Rothman
  • LE Moore
  • Q Lan


Objectives: Trichloroethylene’s (TCEs) carcinogenic potential continues to generate controversy, even after the US Environmental Protection Agency elevated its classification to “carcinogenic.” We conducted a meta-analysis of published cohort and case-control studies exploring occupational TCE exposure in relation to lymphatic and hematopoietic cancers: non-Hodgkin’s lymphoma (NHL, N=24), Hodgkin’s lymphoma (HL, N=13), multiple myeloma (MM, N=11), leukemia (N=12), and chronic/small lymphocytic leukemia (CLL/SLL, N=7). Methods: Studies published from 1950-2011 were identified in PubMed. Studies included in analyses were classified either as those that assessed occupational TCE exposure specifically (“TCE-exposure” studies) or those that assessed a broader classification of chlorinated solvents (“chlorinated solvent-exposure” studies). Results: Significantly elevated NHL summary estimates were observed for cohort and case-control “TCE-exposure” studies combined (N=19; Relative Risk (RR)=1.32, 95% confidence interval (CI)=1.14-1.54; P-heterogeneity=0.12) and for cohort “TCE-exposure” studies (N=10; RR=1.52, 95%CI=1.29-1.79; P-heterogeneity=0.63). A non-significant elevated summary estimate was observed for NHL case-control “TCE-exposure” studies. For “chlorinated solvent exposure” studies no significant NHL risk association was detected. Summary estimates for occupational TCE exposure were not associated with HL, MM, leukemia, or CLL/SLL risk. Conclusion: Our updated NHL meta-analysis which incorporates new analytic results from three cohort and four case-control studies supports an association between occupational TCE exposure and NHL.

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