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DAVID-WS: A stateful web service to facilitate gene/protein list analysis

Friday, November 08, 2013 — Poster Session IV

2:00 p.m. – 4:00 p.m.

FAES Academic Center (Upper-Level Terrace)




  • X Jiao
  • BT Sherman
  • DW Huang
  • R Stephens
  • MW Baseler
  • HC Lane
  • RA Lempicki


The database for annotation, visualization and integrated discovery (DAVID), which can be freely accessed at, is a web-based online bioinformatics resource that aims to provide tools for the functional interpretation of large lists of genes/proteins. It has been used by researchers from more than 5000 institutes worldwide, with a daily submission rate of ∼1200 gene lists from ∼400 unique researchers, and has been cited by more than 10,000 scientific publications. However, the current web interface does not support programmatic access to DAVID, and the uniform resource locator (URL)-based application programming interface (API) has a limit on URL size and is stateless in nature as it uses URL request and response messages to communicate with the server, without keeping any state-related details. DAVID-WS (web service) has been developed to automate user tasks by providing stateful web services to access DAVID programmatically without the need for human interactions. Our performance testing shows that it took about 6–9 s to generate the output for computationally intensive client tasks such as gene functional classification or functional annotation clustering with 2000 genes.

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