Relationship of Vascular Inflammation and Cardiometabolic Risk Factors: The Psoriasis Atherosclerosis Cardiometabolic Disease Initiative

Friday, November 08, 2013 — Poster Session III
10:00 a.m. – 12:00 p.m.	FAES Academic Center (Upper-Level Terrace)	NHLBI	CLIN-5

Authors

J Dave
K Sonti
S Rose
H Naik
M Playford
B Lockshin
P Herscovitch
N Mehta

Abstract

Inflammation is associated with cardiovascular disease (CVD), but the mechanisms remain poorly understood. We utilize psoriasis (PSO), which is associated with increased risk of CVD, to understand links between inflammation and atherosclerosis. FDG-PET/CT imaging was used to determine the association of vascular inflammation (VI) with inflammatory parameters and hypothesized that psoriasis would provide a reliable model to understand inflammatory pathways in CVD. Mean and maximum standardized uptake volume (SUV) were measured in PSO (n=18). Most diseased segment (MDS), indicating the highest amount of VI, was determined by locating the region with the maximum SUV value. Linear regression was used to understand the relationship between the MDS and inflammatory covariates beyond CVD risk factors. The sample had mild inflammation of the skin (body surface area 3.7 (IQR 1.3-7.3)). In fully adjusted models, the MDS by mean SUV were associated with GM-CSF and IL-2 (β 0.99, 1.2, p<0.05) and maximum SUV with GMCSF, IL-10, IL-12p70, IL-1β, and IL-2 (β 1.3, 0.15, 0.05, 0.06, 0.17, 1.8; p<0.05) respectively. We demonstrated that psoriasis provides a reliable model to study the relationship between inflammation and CVD. Furthermore, VI is associated with traditional and inflammatory biomarkers, which may provide novel pathways to study inflammation and CVD.