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The relationship between physical activity, functional performance, and fatigue in sarcoidosis

Friday, November 08, 2013 — Poster Session III

10:00 a.m. – 12:00 p.m.

FAES Academic Center (Upper-Level Terrace)




  • N. Lukkahatai
  • K. Filler
  • L.N. Saligan


Background: Fatigue is a prevalent symptom in sarcoidosis. The etiology and definition of fatigue is uncleared and poorly managed. This pilot study explored the relationships between fatigue, physical activity, and functional performance of pulmonary sarcoidosis patients. Methods: Fourteen biopsy-confirmed, Stage III-IV pulmonary sarcoidosis patients were studied from December 2008 to August 2009. Fatigue was measured using the Fatigue Assessment Scale. Physical activity was measured by actigraphy; functional performance was determined by six-minute walk distance (6MWD) and hand grip dynamometry. Results: Compared with healthy controls, sarcoidosis patients had shorter 6MWD (p = 0.003), lower physical activity for the most active 10 hours (M10) of each day (p = 0.03), and higher fatigue scores (p < 0.0001). In sarcoidosis patients, physical fatigue significantly correlated with depressive symptoms (r = 0.63, p = 0.02), mental fatigue with albumin level (r = -0.58, p = 0.03). Sarcoidosis patients with high fatigue and low depressive symptoms (HFLD) had lower physical fatigue compared to sarcoidosis patients with high fatigue and moderate depressive symptoms (p = 0.01). Conclusions: Pulmonary sarcoidosis is associated with high fatigue, physical inactivity, and low functional performance. Assessments fatigue using physical activity, functional performance, and patient-reported symptom may provide clinical management guidance.

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