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Ghrelin Levels and Fatigue Intensification in Men Receiving Localized Radiation Therapy

Friday, November 08, 2013 — Poster Session III

10:00 a.m. – 12:00 p.m.

FAES Academic Center (Upper-Level Terrace)




  • K.A. Filler
  • N. Lukkahatai
  • L.N. Saligan


PURPOSE: This prospective study explored relationships between plasma levels of ghrelin and intensification of fatigue in men with non-metastatic prostate cancer receiving external beam radiation therapy (EBRT). METHODS: Fatigue, measured by Functional Assessment of Cancer Therapy-Fatigue (FACT-F) and plasma were collected before (day 0), at midpoint (days 19-21), and at completion (days 38-42) of EBRT. Active ghrelin was measured from plasma samples using commercially available ELISA kits. A mixed linear model determined significant associations between ghrelin levels and fatigue. RESULTS: Subjects were 25 men with prostate cancer scheduled for EBRT. The mean FACT-F score for study subjects was 44.87 + 5.89 at baseline, 49.02 + 5.29 at midpoint, and 48.22 + 6.84 at completion of EBRT. 14 subjects were grouped as high fatigue and 9 subjects were categorized as low fatigue based on the FACT-F changed during EBRT. An increase in active ghrelin levels in the low fatigue group trended towards significance (p=.09). CONCLUSIONS: Increased ghrelin level during EBRT may provide a protective mechanism that prevents worse intensification of fatigue during EBRT. Further investigation using a larger sample size is warranted.

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