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Biomechanical markers of multidrug resistance

Thursday, November 07, 2013 — Poster Session II

12:00 p.m. – 2:00 p.m.

FAES Academic Center (Upper-Level Terrace)




  • A. Bhirde
  • A. Jin
  • G. Niu
  • X. Chen


Multidrug resistance (MDR) is a big challenge for successful cancer treatment. Unearthing the markers of drug resistance can help develop efficient chemotherapeutics against MDR. Routine techniques involve cell fixation or genetic modification and or using a fluorescent marker, basically read out in a non-native state. Recent studies have indicated that cell elasticity can be indicative of drug resistance. Here in this study we propose a new way of looking at biomechanical markers of MDR cells using a multimodal multiphasic force microscopy approach. We found several distinct biomechanical signatures that differentiate between drug sensitive and resistant cancer cells near physiological conditions. It’s known that change in biomechanical properties of cancer cells is correlated to disease progression, compromised treatment, and eventual drug resistance. Thus, the changing mechanical behavior of the cells demands consideration when trying to understand the complex nature of MDR.

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