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Non-invasive multimodal optical imaging for monitoring the treatment outcome in patients with Kaposi Sarcoma

Thursday, November 07, 2013 — Poster Session II

12:00 p.m. – 2:00 p.m.

FAES Academic Center (Upper-Level Terrace)

NICHD

BIOENG-1

Authors

  • A Afshari
  • Y Ardeshirpour
  • M Polizzotto
  • K Wyvill
  • K Aleman
  • K Waldon
  • L Najafizadeh
  • R Yarchoan
  • A Gandjbakhche

Abstract

In this study, we used multimodal optical imaging for monitoring the efficacy of treatment in patients with Kaposi Sarcoma. This system is integration of three different optical modalities, laser Doppler, thermal and near-infrared multi-spectral imaging systems. One lesion of each patient was imaged before and every month during the treatment. The captured images were processed to extract the blood flow, temperature, oxy-hemoglobin and total blood volume concentration. In multispectral imaging, the collected images were calibrated and the artifacts generated by curvature of imaging area were removed. The two layered skin model was applied to quantify the oxy-hemoglobin and total blood volume concentration. In this poster, we will present the correlation between the results obtained by our multimodal optical imaging system and the efficacy of treatment in patients with Kaposi Sarcoma.

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