Co-Chairs:
Zu-Hang Sheng, NINDS and Ramanujan Hegde, NICHD

Natcher Conference Center - Main Auditorium

The sorting of proteins among numerous organelles and the trafficking of these organelles within the cell generates a remarkable spatial organization that is critical to cellular function. It is therefore not surprising that a wide range of disease states are associated with problems in organelle biogenesis, function, or trafficking. This minisymposium will discuss recent advances in our understanding of organelle biology ranging from protein import into the endoplasmic reticulum, organelle trafficking by cellular motors, mitochondrial morphology and localization, and regulation of organelle homeostasis. Special emphasis will be place on the potential roles of organelle dysfunction in the development of disease.

Program:

Regulation and Mis-Regulation of Protein Entry into the Endoplasmic Reticulum
Ramanujan Hegde, NICHD

Docking of Axonal Mitochondria Controls Their Mobility and Regulates Neuronal Function
Zu-Hang Sheng, NINDS

Design Principles for Myosin V-Dependent Organelle Transport
John Hammer, NHLBI

Regulation of Organelle Homeostasis by Membrane-associated RING Finger E3 Ubiquitin Ligases
Mariusz Karbowski, NINDS/Maryland Biotechnology Institute