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Home > Concurent Symposium Sessions > A New Non-Invasive Method for Detecting Stress and Immune-Related Biomarkers in Sweat

Concurent Symposium Sessions
  Wednesday, September 26
Natcher Conference Center
Symposia Session II

A New Non-invasive Method for Detecting Stress and Immune-related Biomarkers in Sweat

10:30 am to 12:30 pm

Esther M. Sternberg, NIMH

Natcher Conference Center - Conference Room D

In order to study ambulatory subjects in a non-invasive manner in their usual home and work environment, it is necessary to develop new methods which can detect minute amounts of biomarkers in easily accessible biological fluids and to compare these measures with standard techniques. The development and validation of such new clinical methodologies requires the coordination of an interdisciplinary team of researchers. This symposium will bring together collaborators from relevant fields, including immunochemistry (Dr. Terry Phillips), endocrinology (Dr. Giovanni Cizza) and psychophysiology (Dr. Julian Thayer) to illustrate a case study for development of a method to measure stress and immune-related biomarkers in sweat. The outcome of this study has yielded important information regarding levels of pro-inflammatory cytokines and stress-related neuropeptides in a population of pre-menopausal women with depression who were mostly in clinical remission. The findings indicated that pro-inflammatory cytokines and sympathetic and pain neuropeptides were elevated while the parasympathetic neuropeptide VIP was decreased. These findings have important clinical implications for the enhanced risk of medical illnesses such as osteoporosis or diabetes in depression. Furthermore, the methodology developed through this collaboration can be applied to many settings in which only non-invasive techniques are feasible and in which blood collection is not practical.


Introduction: Interdisciplinary Team Approach to Developing & Validating a Non-Invasive Method for Measuring Stress and Immune Biomarkers in Sweat
Esther M. Sternberg, NIMH

Recycling Immunoaffinity Chromatography: A Method to Detect Minute Quantities of Analytes in Minute Amounts of Biological Fluids
Terry Phillips, NIBIB

The P.O.W.E.R. Study: Osteoporosis in Pre-menopausal Women with Depression: Clinical Validation of Sweat Patch Analytes in this Population
Giovanni Cizza, NIDDK

Ambulatory Measures of Sympathetic and Parasympathetic Nervous System Responses
Julian Thayer, Ohio State University

Summary and Conclusions
Esther M. Sternberg, NIMH

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