Co-Chairs:
Esther M. Sternberg, NIMH
Natcher Conference Center - Conference
Room D
In order to study ambulatory subjects in a non-invasive
manner in their usual home and work environment, it is necessary
to develop new methods which can detect minute amounts of biomarkers
in easily accessible biological fluids and to compare these measures
with standard techniques. The development and validation of such
new clinical methodologies requires the coordination of an interdisciplinary
team of researchers. This symposium will bring together collaborators
from relevant fields, including immunochemistry (Dr. Terry Phillips),
endocrinology (Dr. Giovanni Cizza) and psychophysiology (Dr. Julian
Thayer) to illustrate a case study for development of a method
to measure stress and immune-related biomarkers in sweat. The outcome
of this study has yielded important information regarding levels
of pro-inflammatory cytokines and stress-related neuropeptides
in a population of pre-menopausal women with depression who were
mostly in clinical remission. The findings indicated that pro-inflammatory
cytokines and sympathetic and pain neuropeptides were elevated
while the parasympathetic neuropeptide VIP was decreased. These
findings have important clinical implications for the enhanced
risk of medical illnesses such as osteoporosis or diabetes in depression.
Furthermore, the methodology developed through this collaboration
can be applied to many settings in which only non-invasive techniques
are feasible and in which blood collection is not practical.
Program:
Introduction: Interdisciplinary Team
Approach to Developing & Validating a Non-Invasive Method
for Measuring Stress and Immune Biomarkers in Sweat
Esther M. Sternberg, NIMH
Recycling Immunoaffinity Chromatography:
A Method to Detect Minute Quantities of Analytes in Minute
Amounts of Biological Fluids
Terry Phillips, NIBIB
The P.O.W.E.R. Study: Osteoporosis
in Pre-menopausal Women with Depression: Clinical Validation
of Sweat Patch Analytes in this Population
Giovanni Cizza, NIDDK
Ambulatory Measures of Sympathetic
and Parasympathetic Nervous System Responses
Julian Thayer, Ohio State University
Summary and Conclusions
Esther M. Sternberg, NIMH
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