Co-Chairs:
David Roberts, NCI and Triantafyllos Chavakis, NCI

Natcher Conference Center - Balcony C

Vascular biology is a key to understanding the etiology and pathogenesis of many diseases including developmental disorders, cancer, heart disease, and stroke. Research over the past decade has identified many of the genes and signaling pathways that contribute to the pathogenesis of these diseases. These signaling pathways direct the development of new blood vessels (angiogenesis) and control tissue perfusion, the transport of solutes and macromolecules across the vessel wall, and leukocyte trafficking during inflammatory processes. These insights have provided a foundation for developing new targeted therapeutics to restore normal vascular physiology and limit pathological angiogenesis. This session will highlight recent advances in the areas of vascular biology and angiogenesis by senior and junior scientists from the NIH intramural program including members of the NCI Vascular Biology Working Group.

Program:

VE-cadherin and Vascular Permeability
J. Silvio Gutkind, NIDCR

Novel Aspects of Leukocyte-endothelial Interactions with Regards to Vascular Inflammation and Aangiogenesis
Triantafyllos Chavakis, NCI

Thrombospondin-1 and CD47 Control Vascular Perfusion and Ischemic Tissue Survival
Jeff S. Isenberg, NCI

CXCR4 and Tumor Angiogenesis
Giovanna Tosato, NCI