Co-Chairs:
Roland Owens, NIDDK and Jeffrey Cohen, NIAID

Natcher Conference Center - Conference Room E1/E2

Papillomaviruses, adeno-associated viruses, lentiviruses (such as HIV-1) and herpesviruses are capable of establishing persistent infections by various mechanisms. Persistent viral infections have been implicated in diseases such as AIDS and certain cancers. They also represent a potential threat to immuno-compromised patients (including transplant patients). Many of these same persistent viruses are also being adapted for the long-term expression of therapeutic genes. This symposium will sample cutting edge research on mechanisms of persistence used by these viruses. A better understanding of these mechanisms may lead to novel clinical interventions.

Program:

Hitchhiking on Chromosomes; How Papillomavirus Genomes Persist
Atasi Poddar, NIAID

Episomal Persistence and Preferential Integration of Wild-type Adeno-associated Virus Genomes
Roland Owens, NIDDK

Nucleoprotein Intermediates in HIV-1 DNA Integration
Robert Craigie, NIDDK

Herpes Simplex Virus Type-2 Latency-associated Transcript Expresses a MicroRNA In-Vitro and In-Vivo that Silences a Viral Neurovirulence Factor
Shuang Tang, CBER/FDA