Chaired by:
Andrew Singleton, NIA

Main Auditorium, Natcher Conference Center

This symposium will bring together groups at NIH working at the cutting edge of molecular genetics using genome-wide high-density assays of genetic variation. The flexibility of the Intramural Program of NIH has facilitated the rapid adoption of this methodology and its application to genetic problems that were until recently untenable. The speakers will present data that show the wide utility of this methodology in understanding the role of genetic variation in risk for various traits, including diseases. In particular there will be discussion of the use of these methods in: identifying genetic risk loci for cancer, schizophrenia and bipolar disorder; finding genetic loci that modulate common traits; and, using this approach to find genetic mutations that cause neurological disorders.

Program

Whole genome Analysis of Cancer Susceptibility - CGEMS
Stephen Chanock, NCI

The Genome in Childhood Schizophrenia
Anjene Addington, NIMH

A Genome-wide Association Study Implicates Diacylglycerol Kinase eta (DGKH) and Several other Genes in the Etiology of Bipolar Disorder
Francis McMahon, NIMH

GW-SNP Assay – Association and Beyond
Andrew Singleton, NIA