David Schlessinger, NIA, Chair

Conference Room E1/E2, Natcher Conference Center

There are many important differences between men and women in normal physiology as well as disease susceptibility that may be due to differential X linked gene dosage effects. Asymmetry in X gene dosage may occur through escape from inactivation by many X linked genes that do not have Y alleles, and through genomic imprinting, since men have only Xmat while normal women have both Xmat and Xpat. The recent elucidation of X chromosome genomics should promote rapid progress in illuminating X gene dosage effects contributing to differences in physiology, cognitive function and disease susceptibility between normal men and women.

Program:

Evolution of Primate X Chromosome
James C. Mullikin, NHGRI

Escape from X Inactivation
Laura Carrel, Pennsylvania State University College of Medicine

X Chromosome Gene Dosage and the Serum Proteome
Keith Killian, NCI

X Chromosome Gene Dosage and Gender Differences in Longevity
Carolyn Bondy, NICHD