2003 NIH Research Festival
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Mini-symposia Session II
Wednesday, October 15, 2003
Natcher Conference Center
Causes and Consequences of Genome Instability: The Cell Cycle Connection 2:00 p.m.-3:30 p.m..
Co-chaired by:
Munira A. Basrai, Ph.D.
Principal Investigator, Genetics Branch, CCR, NCI
Mirit I. Aladjem, Ph.D.
Principal Investigator, Laboratory of Molecular Pharmacology, CCR, NCI

Sponsored by the NIH Cell Cycle Interest Group
Main Auditorium, Natcher Conference Center
Most of the genetic information that provides the blueprint for an organism is
contained in the chromosomes of its cells. The maintenance, replication and
segregation of the chromosomes is controlled in part by the mitotic cell division
cycle and checkpoints that ensure the ordered execution of these events. During
each cell cycle, dividing cells are faced with the daunting task of accurately
transferring the entirety of their genomes to their progeny. Failure to orchestrate
chromosomal replication and segregation at the appropriate time during the cell
cycle may lead to chromosomal aberrations, aneuploidy and loss of imprinting,
which are hallmarks of developmental abnormalities and malignancies. This
symposium will focus on events that ensure genomic stability through regulation
of replication timing and chromosomal segregation and on the consequences of
perturbation of these processes in human diseases.
Spatial Genome Organization in Cancer
Tom Misteli, Ph.D.
Principal Investigator, Cell Biology of Gene Expression Group, Laboratory of
Receptor Biology and Gene Expression, CCR, NCI
Roles of BRCA1 in Cell Cycle, Genetic Stability and Tumorigenesis
Chuxia Deng, Ph.D.
Chief, Mammalian Genetics Section, Genetics of Development and Disease
Branch, NIDDK
Consequences of Genomic Instability on Gene Expression Levels
Thomas Ried, M.D.
Principal Investigator, Genetics Branch, CCR, NCI
Novel Interactions of Mitotic Checkpoint Proteins with Kinetochores and
Nucleopores in S. cerevisiae

Munira A. Basrai, Ph.D.
Principal Investigator, Genetics Branch, CCR, NCI
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