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Plenary Sessions
Plenary Session I
Wednesday, October 3

Proteomics: From Protein Structure to Disease Mechanisms
Chaired by Lance A. Liotta, NCI

9:00 a.m. - 10:30 a.m.
Main Auditorium
Natcher Conference Center


The ultimate scientific goal of proteomics is to characterize the information flow within the cell and the organism. This information flow is mediated through, and by, protein pathways and networks. As stimuli fluctuate, and as feed back loops return information, newly formed protein networks rapidly break apart. Consequently, the population state of protein networks is constantly changing from minute to minute within each living cell.

The cause of most human disease lies in the functional disregulation of protein-protein or protein-DNA interactions. Such interactions represent the drug targets of the next decade. In the future, entire cellular networks, not just one disregulated protein, will be the target of therapeutics. The next technologic leap will be the application of proteomic technologies at the bedside. It will soon be possible to analyze the state of protein signal pathways in the disease-altered cells, before, during, and after treatment. This can herald the advent of true patient-tailored therapy.


The speakers in this session will describe powerful new technologies and experimental approaches for elucidating pathogenic alterations in a) protein 3-D structure, b) protein post-translational modifications, and c) global proteomic patterns.

Lance A. Liotta, NCI Proteomics: the Upcoming Revolution in Molecular Medicine
Marius Clore, NIDDK Structural Studies of Protein Complexes by NMR
Donita Garland, NEI Getting Things in Focus: Post Translational Modifications in Development and Pathology of the Human Lens
Emanuel Petricoin III, CBER/FDA Clinical Application of "Artificial Intelligence" Bioinformatics Tools to Discover Diagnostic Proteomic Signatures


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