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Mini-Symposia
Session III
Thursday,
October 4
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New
Transplantation Therapies
Chaired by David M. Harlan, NIDDK
11:00 p.m. to 12:30 p.m.
Natcher
Conference Center
Main Auditorium
Clinicians
have achieved tremendous success with
solid organ transplantation in recent
years due in large part to the development
of new, more potent immunosuppressive
drugs. However, patients require therapy
indefinitely, and are always at risk
for opportunistic infections, certain
malignancies, and suffer with other
drug associated toxicities. Scientists
are working to better understand the
balance between over-immunosuppression
and the prevention of rejection. The
induction of tolerance towards a donor
graft could result in long-term graft
survival in the absence of immunosuppression-associated
morbidity. In this mini-symposium,
investigators in the NIDDK/Navy Transplantation
and Autoimmunity Branch will update
attendees regarding the immunological
mechanisms of rejection and tolerance
induction. Branch investigators will
also present results of current NIDDK
clinical trials in kidney allotransplantation
as well as the progress developing
pancreatic islet transplantation at
a curative therapy for type I diabetes
mellitus.
| Program |
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| Allan
D. Kirk, NIDDK |
Costimulatory
Blockade: Studies in primate models of skin and
kidney transplantation |
| Roslyn
B. Mannon, NIDDK |
Kidney
Transplantation at the NIH: Outcomes, Issues,
and Strategies |
| Douglas
Hale, NIDDK |
Bone Marrow Conditioning in
Solid Organ Transplantation |
| S.
John Swanson, WRAMC/NIDDK |
Sirolimus Monotherapy Following
T Cell Depletion using Polyclonal Anti-Thymocyte
Globulin |
| David
M. Harlan, NIDDK |
Islet Transplantation at the
NIH |
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DNA Repair, Human Disease and
Aging
Chaired by Vilhelm A. Bohr, NIA, and Roger Woodgate,
NICHD
11:00 p.m. to 12:30 p.m.
Natcher
Conference Center
Balcony A
This
workshop focuses on aspects of DNA repair as they
relate to human disease. Human syndromes that are
deficient in DNA metabolic processes will be discussed
and we will focus on proteins that are defective under
those conditions. Thus, DNA repair and replication
proteins will be discussed and also proteins defective
in human diseases of premature aging. Clinical, cell
biological, biochemical and structural studies are
presented.
| Program |
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| Vilhelm
A. Bohr, NIA |
Human
Werner syndrome protein and interactions |
| Kenneth
H. Kraemer, NCI |
Xeroderma
pigmentosum and related disorders
of DNA repair |
| Roger
Woodgate, NICHD and Wei Yang,
NIDDK |
Recent insights
gained from the structural and
biochemical analyses of the Y-family
of DNA polymerases |
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Depression
Chaired by Dennis S. Charney, NIMH
11:00 a.m. to 12:30 p.m.
Natcher
Conference Center
Balcony B
Depression is one
of the most serious and disabling
of all medical disorders. This is
due, in part, to the fact that in
many patients depression starts in
childhood and recurrent episodes occur
throughout the lifespan. Depression
negatively affects outcome in a variety
of other medical conditions including
heart disease and diabetes. Advances
in our understanding of the genetic
and environmental factors that contribute
to depression are urgently needed.
The discovery of the neural basis
of depression and the identification
of new and novel therapeutic agents
are of critical importance. This symposium
will review research approaches to
these problems and will provide an
up to date progress report.
| Program |
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| Dennis
S. Charney, NIMH |
Overview
and Summary |
| Daniel
Pine, NIMH |
Neurobiology
and Treatment of Childhood Onset
Mood Disorders |
| Wayne Drevets,
NIMH |
Neuroimaging
Studies of Mood Disorders |
| Husseini Manji,
NIMH |
Neuroplasticity
and Cellular Resilience in Mood
Disorders |
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Autoimmune
Diseases: Antibodies as Predictors
Chaired by Abner L. Notkins, NIDCR, and Peter Lipsky,
NIAMS
11:00 a.m. to 12:30 p.m.
Natcher
Conference Center
Balcony C
With
the emphasis in recent years on cell-mediated immunity
and the identification of disease-specific genes,
the role of B cells and antibodies in the pathogenesis
of autoimmune diseases has taken a back seat. In this
mini-symposium five major autoimmune diseases - type
1 diabetes, thyroid disease, muscle disease, multiple
sclerosis and systemic lupus erythematosus - will
be discussed. Evidence will be presented showing how
at least in some of these diseases B cells and autoantibodies
contribute to pathogenesis and how the repertoire
of autoantigen targets may be selected. Since in many
cases autoantibodies precede the development of clinical
disease by months or years, autoantibodies are now
being used not only for diagnosis but also as predictive
markers for identifying individuals at high disease
risk and for estimating disease progression. The value
of autoantibodies in providing therapeutic paradigms
will be discussed and comparisons will be made with
genetic and other surrogate disease markers.
| Program |
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| Abner
L. Notkins, NIDCR |
Type1
Diabetes: Autoantibodies as Predictors of Disease |
| Leonard
Kohn, NIDDK |
Autoantibodies
in Graves' Disease: New Assay Techniques and Epitope
Mapping Suggest They May Predict Disease Expression
and Determine Therapy |
| Paul
Plotz, NIAMS |
What are the Autoantibodies
in Myositis Trying to Tell Us? |
| Henry
McFarland, NINDS |
Multiple Sclerosis:
A Humoral or Cell-Mediated Immune Process? |
| Peter
Lipsky, NIAMS |
Systemic Lupus
Erythematosus: The Prototypic Systemic Autoimmune
Disease |
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Minority
Health and Health Disparities
Chaired by John Ruffin, NCMHD
11:00 a.m. to 12:30 p.m.
Natcher
Conference Center
Conference Room E1/E2
The
National Center on Minority Health and Health Disparities
is sponsoring a mini-symposium that will feature NIH
scientists who are conducting groundbreaking, new
discoveries in the areas of minority health and health
disparities. The major purpose is to highlight research
studies in the areas of basic, clinical, and behavioral
science.
| Program |
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| Jay Hoofnagle, NIDDK |
Hepatitis
C in African Americans |
| John Carpten, NHGRI |
Prostate Cancer: the African
American Hereditary Prostate Cancer Study Network |
| Eric J. Bailey, NCMHD |
Medical Anthropology and African
American Health: Solving the Health Disparity
Issue |
| Michele Evans, NIA |
HANDLS: The Birth of a Community-Based
Longitudinal Study |
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EUREKA
II! - - The Scientific Discovery Behind Today's Medical
Products
Chaired by Steven Ferguson, OD
11:00 a.m. to 12:30 p.m.
Natcher
Conference Center
Conference Room F1/F2
Scientists
in the NIH intramural research program dedicate their
careers to discovery, uncovering new knowledge that
leads to better health for everyone. Most often their
work results in scientific publications. Sometimes
their work results in patentable discoveries that
form the basis for new vaccines, drug products, and
devices, among others. These discoveries are transferred
to the commercial partners for development into products
through the process of technology transfer. Since
1993, the NIH Office of Technology Transfer has signed
over 1200 license agreements that govern the terms
of commercialization for a particular invention. In
1999, the Department of Commerce reported that the
NIH generates two-thirds of all royalty income within
the U.S. Government. This symposium will feature current
NIH investigators whose discoveries have contributed
significantly to this NIH public health success story.
These scientists will share their journeys, sometimes
traveled over serendipitous and difficult roads, from
initial discovery to seeing their ideas commercialized
into products.
| Program |
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| Robert
Yarchoan, NCI |
Treatment
of HIV Infection with ddI |
| Robert
M. Chanock, NIAID |
Monoclonal
Antibody for Prevention and Treatment of Respiratory
Syncytial Virus |
| Robert
S. Balaban, NHLBI |
Enhanced Magnetic
Resonance Imaging Through Magnetization Transfer |
| Hynda
K. Kleinman, NIDCR |
Reconstituted Basement
Membrane Complex |
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